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Career Profile
Physician Executive  ·  Enterprise CMIO  ·  AI Governance

Most healthcare AI does not fail because the model is weak. It fails because governance is weak, workflows are wrong, and no one owns accountability after go-live.

I am a physician executive who works in that gap, where clinical leadership, AI governance, and legal accountability intersect.

MD · MBA · MSc JD Candidate FAAP · FHIMSS CHCIO · CEDS · CCISO HIMSS Co-Chair 11 Books Published
45+
Clinical AI Apps
11
Books
85+
Keynotes
Dr. Ryan Sadeghian MD MBA MSc
As Seen In
~90%
Documentation Backlog Reduction
First ambient AI deployment in Northwest Ohio
$4.2M→$72K
EMR Support Contract Reduction
Single fiscal year
50%+
Payer Denial Reduction
Across inpatient and ambulatory
18%→97%
Clinician Engagement
Following $235M Epic transformation
600+
AI-Driven Clinical Workflows
Deployed across health system environments
$5M+
Revenue Recovered
Through AI-redesigned coding and preauthorization
Dr. Ryan Sadeghian
CHCIOCEDSCCISO CHCCHPCCISM ABAIMPMPFAAP FHIMSSMDMBAMSc

About Dr. Ryan Sadeghian

My path into clinical informatics was not a pivot. It was a progression.

I trained first as a pediatrician because I wanted to understand medicine from the bedside, the clinical reality, the documentation burden, the moments where the system either supports or fails the physician trying to care for a patient. That foundation never left. It is why my approach to AI and informatics is clinical first, not technology first.

I hold dual fellowship training in Clinical and Biomedical Informatics from the University of Washington and the University of Pittsburgh, with post-doctoral NIH-funded training in machine learning at the National Library of Medicine. That combination means I can evaluate an AI model's design, deploy it inside a real clinical environment, measure whether it changes outcomes, and defend it when it is challenged clinically or legally.

Healthcare AI is only as good as the clinical and operational infrastructure around it. I have spent my career building that infrastructure, and fixing it when it fails. Over the past decade I have founded a 55+ FTE Clinical Informatics Department, directed a $235M Epic transformation, deployed the first ambient AI documentation program in Northwest Ohio, and reduced enterprise payer denials by over 50%. I owned them, staffed them, and was accountable for their outcomes.

I currently serve as Enterprise Chief Medical Information Officer and Medical Director of AI at University of Toledo Health, Co-Chair of the HIMSS Physician Committee, and Founding Co-Chair of the inaugural HIMSS AI Committee. I am also a JD candidate focused on healthcare law and AI liability, because the legal and regulatory questions around clinical AI are no longer hypothetical. I am one of only eight professionals worldwide holding all three CHIME informatics certifications.

Clinical Informatics
Founded 55+ FTE Clinical Informatics Department
Built and launched University of Toledo Health's Clinical Informatics Department from the ground up, growing it to over 55 full-time staff across six operational pillars.
Epic Governance
Directed $235M Epic Transformation
Led enterprise-wide Epic implementation moving clinician engagement from 18% to 97%, consolidating legacy systems and establishing long-term governance infrastructure.
Ambient AI
First Ambient AI Deployment in Northwest Ohio
Led the region's first ambient AI documentation program across 40 providers and 3,000+ encounters in 8 weeks, reducing documentation backlog by approximately 90%.
Revenue Cycle
Reduced Enterprise Payer Denials by 50%+
Deployed AI-driven CDI tools and utilization management automation that cut enterprise denial rates by more than half across inpatient and ambulatory environments.
Vendor Strategy
Cut EMR Support Contracts from $4.2M to $72K
Negotiated and restructured over 145 vendor contracts. Reduced third-party EMR support expenditure in a single fiscal year through internal capability building and strategic renegotiation.
HIMSS Leadership
Co-Chair, HIMSS Physician and AI Committees
Co-Chair of the HIMSS Physician Committee and Founding Co-Chair of the inaugural HIMSS AI Committee. One of four national members of the HIMSS AI Advisory Group. Featured in Forbes on healthcare AI risk and safety.

Work With Me

AI governance fails quietly. Until it does not.

I work with health systems and health-tech companies on the part of AI that most organizations underestimate, not buying it, but making it operationally defensible.

For Health Systems  ·  CEO · COO · CFO · CMIO · CIO

AI Governance and Clinical Transformation

You bought AI. Now it has to actually work. Most health systems that have deployed AI are managing a version of the same problem: adoption is lower than projected, ROI is hard to demonstrate, and governance is informal. I work specifically in that gap as a physician executive who has deployed AI inside a real health system, tied it to workflow, and built the governance infrastructure that makes it defensible.

  • AI Readiness and Governance Audit (6 to 8 weeks)
  • AI Failure Recovery Advisory
  • Fractional CMIO Engagement
  • Epic AI Optimization Review
  • Physician Adoption and Change Management
For Health-Tech & Startups  ·  Founder · CMO · CPO · VC · PE

Clinical Validation and Enterprise Market Fit

Your product works in the demo. The problem is what happens inside a real health system. I have been on the buying side, evaluating AI vendors, managing physician resistance, and explaining AI failures to a board. I know why enterprise sales stall, where clinical validation claims fall apart, and what a health system compliance team will ask before approving a contract.

  • Clinical Validation and Workflow Assessment
  • Enterprise Sales Enablement
  • AI Due Diligence for VC and PE
  • Regulatory Pathway Guidance
  • Monthly Advisory Retainer
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Media & Appearances

HIMSS TV · Podcasts · Press

Speaking

85+ Keynotes and Public Speaking Engagements

Dr. Ryan Sadeghian has delivered 85+ keynotes and public speaking engagements across national conferences, health system executive forums, and health law CLE programs. Separately, he has delivered over 300 invited educational presentations to physician residents, fellows, and medical students at academic medical centers nationwide.

  • 2026
    HIMSS Global Conference, Las Vegas · Keynote
    AI Governance and Responsible Deployment
  • 2026
    Becker's Hospital Annual Conference, Chicago · Featured Session
    AI Implementation and ROI Accountability
  • 2025
    HIMSS AI Leadership Strategy Summit, Chicago · Live Podcast Panel
    HIMSSCast × Straight Outta Health IT
  • 2025
    HIMSS AI Forum, Chicago · Featured Speaker
    Clinical AI Governance Frameworks
  • 2025
    Health Impact Forum, New York · Keynote
    AI Risk and Legal Accountability in Clinical Environments
  • 2023
    HIMSS23 Global Conference · HIMSS TV Feature
    ChatGPT in Healthcare, Potential and Limitations
Signature Topics
Where Healthcare AI Breaks and What It Costs
AI Governance Without Teeth: Why Most Frameworks Fail
The Accountability Gap: Legal and Clinical Risk in Deployed AI
From Pilot to Production: Making AI Operationally Defensible
EHR Forensics and the Future of Clinical Documentation Integrity
Physician-Led AI: Building Trust, Not Just Tools
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Published Works

11 Books on Amazon

AI in healthcare, clinical leadership, informatics, pediatrics, law, and physician finance by Dr. Ryan Sadeghian.

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Insights

Writing on AI, Governance, and Clinical Transformation

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What Colleagues Say

Trusted by Clinicians, Informaticists, and Leaders

Dr. Sadeghian is an incredibly talented individual. He is methodical and quality-minded in his approach to his work. Coupled with his extensive formal training and his ability to effectively communicate complex technical concepts, he makes an excellent leader and teacher.
R. Glick
Healthcare Executive
Dr. Sadeghian exemplifies the new breed of thoughtful innovators that will take healthcare technology to the next level. He is passionate, hard-working, and always exhibits leadership with contagious enthusiasm for all informaticians to strive to make things better for his colleagues, patients, and healthcare overall.
A. Mohan
Healthcare Technology Leader · 13-year collaborator
He is able to make complex problems appear simple and is expert in communicating goals to fellow team members. A results-driven, tenacious visionary who deftly incorporates the talent of others to accomplish difficult goals.
D. Migita
Physician · Seattle Children's Hospital

Contact

Start a conversation.

For health system advisory, AI governance consulting, speaking engagements, health-tech advisory, and general inquiries. All messages go directly to Dr. Sadeghian.

Health Systems
AI governance, Epic strategy, clinical transformation advisory
Health-Tech & Startups
Clinical validation, enterprise fit, due diligence, advisory
Speaking & Media
Keynotes, executive education, podcasts, editorial
Books & Publishing
Media inquiries, bulk orders, foreign rights
Send a Message

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